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PEC Original Annotations
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Essentiality
|
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Class
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non-essential
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|
References (PMID)
|
Mol Microbiol. 1997;26(5):1013-21.
Expression of gpsA encoding biosynthetic sn-glycerol 3-phosphate dehydrogenase suppresses both the LB- phenotype of a secB null mutant and the cold-sensitive phenotype of a secG null mutant.
Shimizu H, Nishiyama K, Tokuda H.
(
9426138
)
|
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Deletion
|
OCL09
(D)
,
OCL09-9
(D)
|
|
Related gene (W3110 PEC)
|
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Gene Search
|
Search MG1655 PEC by gene name:
secB
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
secB
Search strains by all related name:
secB b3609 ECK3599 f155 JW3584
|
General information (Go to Linear View: )
|
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Gene Name
|
secB
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Alternative name
|
b3609,ECK3599,f155,JW3584
|
|
Location, Length
|
3,781,684 - 3,782,151
(
-
)
;
81.51
min
;
468
(bp) ,
155
(aa)
|
|
Product
|
protein export chaperone
|
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Operon Name
|
secB-gpsA
|
|
Note
|
protein export; molecular chaperone; may bind to signel sequence; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006457 - protein folding
|
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Function
|
transport; Protein, peptide secretion
|
|
Gene Ontology
|
GO:0005737
;
cytoplasm ( secB )
GO:0006457
;
protein folding ( secB )
GO:0006810
;
transport ( secB )
GO:0015031
;
protein transport ( secB )
GO:0051082
;
unfolded protein binding ( secB )
GO:0051262
;
protein tetramerization ( secB )
GO:0065002
;
intracellular protein transport across a membrane ( secB )
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PID
|
1790038
|
EC number
(KEGG Pathway)
|
|
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SWISS-PROT
(
Show details
)
|
Entry name(Acc.no)
|
SECB_ECOLI
(
P15040
)
|
|
- Protein name
|
Protein-export protein secB.
|
|
- Synonyms
|
|
|
- Gene name
|
OrderedLocusNames=b3609, c4432, z5036, ECs4487, SF3648, S4120;
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Homology Analysis
|
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BLAST
|
|
Bacteria
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GTOP
|
secB
(
homologous genes of other bacterias
)
|
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PDB
(database updated :
2007.02.20
)
|
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PSI-BLAST
|
Chain A, Crystal Structure Of Secb From Escherichia Coli
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Protein-export protein secB
|
|
PSI-BLAST
|
Protein-export protein secB
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
export protein SecB [Escherichia coli CFT073]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
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PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
CK2_PHOSPHO_SITE
MYRISTYL
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MMBR References
|
J Bacteriol. 1993;175:4036-4044
prlA supression of defective export of maltose-binding protein in secB mutants of Escherichia coli.
Francetic, O., M. P. Hanson, and C. A. Kumamoto.
|
J Bacteriol. 1992;174:5219-5227
Involvement of SecB, a chaperone, in the export of ribose-binding protein.
Kim, J., Y. Lee, C. Kim, and C. Park.
|
J Biol Chem. 1995;270:22831-22835
Diverse effects of mutation on the activity of the Escherichia coli export chaperone SecB.
Kimsey, H. H., M. D. Dagarag, and C. A. Kumamoto.
|
Mol Microbiol. 1991;5(1):19-22.
Molecular chaperones and protein translocation across the Escherichia coli inner membrane.
Kumamoto CA.
(
1673017
)
|
J Bacteriol. 1983;154(1):253-60.
Mutations in a new gene, secB, cause defective protein localization in Escherichia coli.
Kumamoto CA, Beckwith J.
(
6403503
)
|
J Bacteriol. 1985;163(1):267-74.
Evidence for specificity at an early step in protein export in Escherichia coli.
Kumamoto CA, Beckwith J.
(
3891730
)
|
EMBO J. 1989;8:2703-2709
Three pure chaperone proteins of Escherichia coliSecB, trigger factor and GroELform soluble complexes with precursor proteins in vitro.
Lecker, S., R. Lill, T. Ziegelhoffer, C. Georgopoulos, P. J. Bassford, C. A. Kumamoto, and W. Wickner.
|
J Bacteriol. 1987;169(12):5408-15.
Sequence analysis, transcriptional organization, and insertional mutagenesis of the envA gene of Escherichia coli.
Beall B, Lutkenhaus J.
(
2824434
)
|
J Bacteriol. 1995;177:1906-1907
Export of periplasmic galactose-binding protein in Escherichia coli depends on the chaperone SecB.
Powers, E. L., and L. L. Randall.
|
J Bacteriol. 1988;170(8):3404-14.
Nucleotide sequence of the secA gene and secA(Ts) mutations preventing protein export in Escherichia coli.
Schmidt MG, Rollo EE, Grodberg J, Oliver DB.
(
2841285
)
|
Cell. 1989;58(4):695-705.
SecB functions as a cytosolic signal recognition factor for protein export in E. coli.
Watanabe M, Blobel G.
(
2548733
)
|
Proc Natl Acad Sci U S A. 1995;92:10133-10136
High-affinity binding of Escherichia coli SecB to the signal sequence region of a presecretory protein.
Watanabe, M., and G. Blobel.
|
| Sequences |
Amino acid
FASTA format
|
0001 MSEQNNTEMT FQIQRIYTKD ISFEAPNAPH VFQKDWQPEV KLDLDTASSQ LADDVYEVVL RVTVTASLGE
0071 ETAFLCEVQQ GGIFSIAGIE GTQMAHCLGA YCPNILFPYA RECITSMVSR GTFPQLNLAP VNFDALFMNY
0141 LQQQAGEGTE EHQDA
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 tggatgcacg tggtggactg gatcccctgc
-070 tgaaataacg tgtgaacgtt ggcattacat tgcgcagtat ttaaggacaa cacttaaggg ttttctacac
0001 atgtcagaac aaaacaacac tgaaatgact ttccagatcc aacgtattta taccaaggat atctctttcg
0071 aagcgccgaa cgcgccgcac gttttccaga aagattggca accagaagtt aaacttgatc tggatacggc
0141 atcttcccaa ctggcagatg acgtatacga agtggtactg cgtgttaccg taacggcctc tttgggcgaa
0211 gaaaccgcgt tcctgtgtga agttcagcag ggcggtattt tctccatcgc gggtatcgaa ggcacccaga
0281 tggcgcattg cctgggagca tactgcccga acattctgtt cccgtatgct cgtgagtgca tcaccagcat
0351 ggtatcccgc ggtacattcc cgcaactgaa ccttgcgccg gttaacttcg atgcgctgtt catgaactat
0421 ttgcagcagc aggctggcga aggtactgaa gaacatcagg atgcctgatg aaccaacgta atgcttcaat
0491 gactgtgatc ggtgccggct cgtacggcac cgctcttgcc atcaccctgg caagaaatgg ccacgaggtt
0561 gtcctctg
|
